RNase-free RNA Removal (Magnetic Beads)
We have developed RNase-free RNA Removal (Magnetic Beads) to remove RNA contamination in DNA samples based on Solid Phase Reversible Immobilization (SPRI) beads without using RNase A. DNA extraction is one of the essential steps in the field of molecular biology. However, it is common that the extracted DNA is contaminated with RNA, and it is critical to remove RNA contamination from the DNA samples to reduce the impact on the downstream applications.
RNase A is a popular enzyme for the removal of RNA from DNA samples. However, an RNase-free environment is required for laboratories working with RNA samples because the use of RNase can cause the degradation of RNA samples, leading to poor sample quality and inaccurate experiment results. The conflict of RNA removal by RNase and RNase-free environment still exists in the laboratories.
Our RNase-free RNA Removal (Magnetic Beads) solved the conflict by combining the reversible DNA-binding properties of SPRI magnetic beads with BioDynami’s unique chemistries. The magnetic beads effectively removes RNA and recovers DNA in the same step without using RNase A. Moreover, unwanted components such as salts, enzymes, proteins, and other impurities can also be removed.
The purified DNA can be used for downstream applications such as enzymatic treatment, microarray. PCR, QPCR, and next generation sequencing (NGS). Â The magnetic beads can be an effective and inexpensive reagent for RNA removal for routine DNA purification for laboratories that require an RNase-free environment.
Features
- RNase-free environment compatible
- Effective removal of RNA without RNase A
- High recovery rate of DNA
- Low elution volume
- As low as 10 µl
- Simple and fast beads-based protocol:
- Less than 20 min
- Removal of unwanted components and impurities
Protocol & MSDS Download
Kit Components
- Cat.# 47061S: 5 ml
- Cat.# 47061L: 20 ml
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